Furyk is through two rounds at 11-under-par 131, two shots ahead of four players tied for second place. He finished off his round with a 55-foot birdie putt at the 18th hole, his 13th birdie of the tournament.
Aaron Baddeley also had a great finish, holing out from the fairway at the par-4 18th for an eagle -- just the third eagle at the hole since 1983.
The shot gave Baddeley a 4-under 67 and vaulted him into a share of second place with first-round leader Vaughn Taylor (70), Brian Gay (67) and Duffy Waldorf (68) at 9-under-par 133.
'I didn't realize it went in, but that was a great way to finish,' said Baddeley.
Geoff Ogilvy and Billy Mayfair both shared the lead with Furyk late in their rounds, but finished the day in a tie for sixth place at 8 under after rounds of 68 and 69, respectively.
Fred Funk (66) and Tom Pernice, Jr. (69) are also at minus-8.
Furyk couldn't keep up the bogey-free pace he set in his first round, but six birdies made up for the two shots he dropped.
The 2003 U.S. Open winner reached 11 under with four birdies on his first seven holes. Each one came on putts longer than 8 feet, including a 16-footer at the par-5 fifth and an 18-footer at the par-4 sixth.
Furyk quickly dropped two shots with consecutive bogeys at Nos. 8 and 9, three-putting on both holes to make the turn at 9 under.
Furyk's next birdie -- at the par-5 15th -- gave him at least a share of the lead for good. Three holes later, he drained his 56-footer to move two ahead.
'I ran into a little tough spot today with a couple of bogeys and was able to fight through it and play solid starting out the back nine,' said Furyk. 'I had a couple of putts that could have gone in but didn't, [but I] still birdied 15 and 18 and kept a good day going out there.'
Furyk has improved his finish each of the last four times he has played in this event, culminating in a tie for second place last year. His 7-under 64 in the first round, which put him one stroke behind Taylor overnight, was his best Harbor Town Golf Links round ever.
Fourteen players are within five shots of the lead heading into the weekend.
Tim Clark fired the round of the day with a 6-under 65. Last week's runner-up at The Masters, Clark is tied for 16th place at 5 under with seven other players. Among them are John Daly (67) and 50-year-old Loren Roberts (69).
World No. 5 Ernie Els is one shot further back at minus-4 and certainly not out of it. Els, the highest-ranked player in the field, shot a 4-under 67 on Thursday.
Defending champion Peter Lonard made the cut by two shots at 1-under-par 141 after a second-round 70.
Among those who missed the even-par cut line were Irishman Paul McGinley, three-time Masters champion Nick Faldo, two-time Masters winner Jose Maria Olazabal, reigning Rookie of the Year Sean O'Hair and up-and-comer Camilo Villegas.