The Irwin family finally won this title after three runner-up finishes. They took second the last two years, including a playoff loss last year to the Stadlers.
'We didn't realize we were in the lead,' admitted Hale Irwin. 'The difference this year is that Steve has gone from being an inexperienced player to an experienced player.'
The Irwins collected $200,000 for the win.
Larry and Josh Nelson finished in third place at 19-under-par 125 after a final-round 62.
Overnight leaders Bernhard and Stefan Langer (65), 2002 winners Craig and Kevin Stadler (61), Tom and David Kite (62) and Vijay and Qass Singh (60) shared fourth place at 18-under-par 126.
This unique format allows fathers and sons to compete together in a scramble. The fathers must have won a major championship and this year there is a grandfather and grandson playing. Arnold Palmer and his grandson Sam Saunders were in the field.
The Irwins were in the clubhouse at 21-under par but the Nicklaus family had a chance to force a playoff if they could muster an eagle. They only managed birdie so it was the first title for the Irwin family.
'The bottom line is the Irwins played better than us by a shot,' said Jack Nicklaus. 'It was fun to be right in the hunt.'
Raymond and Robert Floyd, two-time winners of this event, combined for a 10- under 62 in the final round and shared eighth place with Dave and Ron Stockton, who also shot a 62 on Sunday. The pair finished at 16-under-par 128.
Johnny and Scott Miller took 10th at minus 14.
Hale Irwin/Steve Irwin, $200,000 62-61-123
Jack Nicklaus/Jack Nicklaus II, $105,000 62-62-124
Larry Nelson/Josh Nelson, $80,000 63-62-125
Vijay Singh/Qass Singh, $54,750 66-60-126
Craig Stadler/Kevin Stadler, $54,750 65-61-126
Tom Kite/David Kite, $54,750 64-62-126
Bernhard Langer/Stefan Langer, $54,750 61-65-126
Raymond Floyd/Robert Floyd, $47,500 66-62-128
Dave Stockton/Ron Stockton, $47,500 66-62-128
Johnny Miller/Scott Miller, $46,000 66-64-130
Mark O'Meara/Shaun O'Meara, $45,000 63-68-131
Arnold Palmer/Sam Saunders, $44,000 65-67-132
Lee Trevino/Tony Trevino, $42,500 67-67-134
Lanny Wadkins/Travis Wadkins, $42,500 70-64-134
Jerry Pate/Wesley Pate, $41,000 66-70-136
Seve Ballesteros/Javier Ballesteros, $40,000 70-72-142
Full Coverage of the Office Depot Father/Son Challenge