'You keep trying,' said Lane. 'It's been a great day, a great week.'
The Englishman finished at 16-under-par 272 after a gutsy back nine for his fifth career victory on the European Tour.
Argentina's Eduardo Romero joined fellow countryman Angel Cabrera in a tie for second at 13-under-par 275. Patrik Sjoland of Sweden was one shot further back at 12-under-par 276.
Lane played in the last group on Sunday at the Forest of Arden alongside 54-hole leader Paul Broadhurst, who was looking to end a winless streak of his own.
While several players made early runs, such as Nick O'Hern, who birdied each of his first four holes, Lane prevailed with solid play on the front nine.
Lane picked up his first birdie at the par-5 third and left his tee shot within 6 feet of the hole at the par-3 fifth. He drained the putt to reach 12 under before taking on the par-5 seventh.
The 43-year-old blasted his second shot through the green but chipped in for an eagle to pull two shots ahead into the outright lead.
'That was nice,' Lane said of his eagle at the seventh. 'Obviously to chip it in is a bonus.'
Lane coasted from that point on, but needed some key shots on the inward half to hold off his competitors.
He tallied a birdie at the 12th to open a three-shot advantage but three-putted for a bogey at the par-3 15th.
Lane looked to be in trouble again at the par-4 16th after his drive landed in the thick rough. He buckled down, however, and sent his second shot over the water protecting the putting surface and watched as his ball stopped safely on the green.
'The 16th was the key hole,' said Lane. 'I pushed the drive and that was possibly the worst lie I have ever seen. To get it on the green was unbelievable.'
Lane had a lengthy putt left for birdie and drained it to return to 15 under. He then went after the par-5 17th and chipped his third from off the green to 4 feet for another birdie to secure his first victory since the 1994 Turespana Open de Baleares.
Romero got off to a quick start on Sunday with a birdie at the par-4 second after his approach came within inches of the cup and he added a birdie at the third to jump into the lead.
The 49-year-old, who was trying to become the oldest winner in European Tour history, cooled down around the turn before a birdie at the 15th moved him within two of Lane.
Romero's title hopes were derailed on the 16th green, however, where he struggled to a three-putt bogey. He responded with a 5-footer for birdie at the 17th to join Cabrera in a tie for second.
O'Hern, who did not collect a single birdie after his birdied-filled start, carded a 68 to finish at 11-under-par 277 along with Darren Clarke, Anders Hansen and Broadhurst.
Alastair Forsyth was one shot further back at 10-under-par 278.