Tripp Isenhour, Rick Price and Jason Schultz share second place at 9-under- par 134.
Thunderstorms delayed action on Friday forcing the second round to be completed on Saturday.
Meeks began his second round at minus-7. He dropped a stroke with a bogey at the par-3 seventh. Meeks recovered that stroke at the next with a birdie, then carded another birdie at the par-5 ninth.
On the back side, Meeks stumbled with a bogey at the par-3 11th. He then notched three birdies over a four-hole span starting at the 14th to get to minus-10.
Golfers will move to the Cliffs Valley course for the final two rounds after rotating between par-72 Cliffs Valley layout and the par-71 Cliffs at Keowee Vineyards for the first two rounds.
Jack Nicklaus is participating in his first Nationwide event and played with sons Gary, Michael and Jackie, and his amateur partner was his fourth son Steve.
Jack Nicklaus made the cut at 5-under-par 138, while the other three missed the cut. Gary finished at 3-over-par 146, Michael was one stroke behind him and Jack II was well back at 9-over-par 152.
Charles Warren, the 2002 Charity Pro-Am winner, stumbled to a 1-over 73 in the second round and missed the cut at 1-under-par 142. The cut line fell at minus-2 141.