Tournament officials shortened the event to 54 holes, the first time that has happened on the Nationwide Tour since the 2002 Nationwide Tour Championship.
Australia's Mathew Goggin posted a 7-under 65 on Friday to take the lead through two rounds. He stands at 12-under-par 131 and leads by two over Bubba Watson.
The format features each player joined by an amateur partner or a celebrity, like the AT&T Pebble Beach National Pro-Am on the PGA Tour.
For the first time in Nationwide Tour history, play is spread throughout three courses - The Cliffs Valley Course at the Cliffs Golf & Country Club, The Cliffs at Keowee Vineyards and The Cliffs at Walnut Cove. The Cliffs Valley Course is a par-72 layout, while the other two are par 71s.
Goggin's 65 came at the Cliffs Valley Course. Watson shot a 7-under 64 at the Keowee Vineyards Course and is 10 under par for the tournament.
Jon Mills, one of three first-round co-leaders, shot a 2-under 70 at Cliffs Valley and is alone in third place at 9-under-par 134.
Charley Hoffman, Joseph Alfieri, Kyle Thompson, Scott Weatherly, Andrew Johnson and Robert Garrigus, who fired a 10-under-par 62 on Friday at Cliffs Valley, are tied for fourth place at minus-8.