Craig Bowden also posted a 66 to move into solo third place at 11-under-par 133, while Charles Warren is one stoke further back at minus-10.
Skinner started quickly on the front nine at The Dominion Club. He rolled off two straight birdies to open his round. He picked up his third birdie of the day at the seventh, however he stumbled to a bogey at the next.
Around the turn, Skinner played steady golf. He parred the first five holes on the back side and then the 32-year-old rolled in back-to-back birdies from the par-4 15th.
Skinner closed out his round in fine fashion as he eagled the last to grab a share of the lead.
'I haven't been playing too good so it's hard to feel comfortable,' said Skinner, who earned his second Nationwide Tour win on this course nine years ago. 'You go some place where you've had success before, and you're at the bottom anyway, so you're looking for some hope.'
Skinner has gotten several tips recently from fellow pros that have helped his all around game this week.
'Vic Schwamkrug gave me a tip on how to hit my driver a little better and Bubba Watson gave me some insight on my putting,' Skinner said. 'I've been looking for some help because Lord knows I've been needing it. I hope I can keep it going.'
Van Pelt, who shared second place with Skinner and five others entering the round, started on the back side with consecutive birdies from the 11th. He moved to 9-under with a birdie at the par-4 15th.
On the front side, Van Pelt picked up his fourth birdie of the round at No. 2. However, he dropped a shot at the next. He quickly erased that mistake with a birdie at the par-5 fourth.
Van Pelt capped his round with back-to-back birdies from the sixth for his share of the lead.
'I'm hitting a lot of greens this week,' Van Pelt said. 'It's like any week when you shoot two 66s, you've probably putted pretty good, and I have. I haven't put a lot of pressure on myself to make a lot on long putts.'
Wes Short, Roger Tambellini and Bubba Dickerson each carded rounds of 5- under 67 to move to 9-under-par 135. That trio shares fifth place with overnight leader Tom Carter, Daniel Chopra, Chris Zambri and Zach Johnson.
The cut line fell at 4-under-par 140 with 63 players surviving to play the weekend. Joe Ogilvie, who has two wins this season, struggled to rounds of 74-79 for a two-round total of 9-over-par 153.