Charley Hoffman, Jerry Smith and Brendon De Jonge share second place at 6-under-par 64. Steven Bowditch, who won the Jacob's Creek Open earlier this season, is one stroke further back at minus-5. He was joined there by Jon Mills, Steve LeBrun, Anthony Painter and Jason Dufner.
Snedeker began on the back nine at Troy Burne Golf Club and promptly birdied his first hole. After four straight pars, he drained a birdie on the par-3 15th.
The 24-year-old made it two straight as he birdied the 16th. Snedeker made the turn at minus-4 thanks to a birdie on No. 18.
Snedeker made it two in a row as he birdied the first. The Vanderbilt alum sank a birdie try on the second to cap a run of three straight birdies.
He dropped in another birdie putt on the fourth, but tripped to a bogey on the sixth. Snedeker closed with a birdie on No. 9 to take the first-round lead.
Jason Schultz, Tim Simpson, Eric Axley, Dave Christensen and Doug Garwood are tied for 10th place at 4-under-par 66.
Jason Gore, who won the Pete Dye Classic last week, is one stroke further back at minus-3.