Stanford stands at 18-under-par 198 through three rounds, smashing the 54-hole record of 204 established by Lorena Ochoa in 2004. She will be looking for her second LPGA title on Sunday, and first in three years.
'I'm a big believer in you have to learn how to win,' said Stanford. 'And I feel like I might be learning all over again, almost.'
Cristie Kerr also shot a 66 on Saturday to move into a tie for second place at 14-under-par 202. She could just as easily be a couple of shots closer to Stanford if not for two near-misses on the back nine.
'[I] almost made two shots from the fairway on 14 and 17, both of them coming unbelievably close because I asked the crowd,' said Kerr. 'I just played really, really well and played with a lot of confidence. I feel like I'll have a good shot at it tomorrow.'
Sophie Gustafson -- who set a new course record in the second round with a 63 -- is also at minus-14 after carding a 4-under 68 in her third round at the Iron Horse Course at Vanderbilt Legends Course.
Sharing fourth place at 13-under are Pat Hurst (66), Ji Yeon Lee (67) and Patricia Meunier-Lebouc, who dropped from second place overnight after a 2-under 70.
Steady at the start with six straight pars to begin her round, Stanford caught fire beginning on the seventh, where she collected the first of five straight birdies after knocking a bunker shot within 8 feet.
'I started off kind of shaky and made a birdie on seven, and I finally got comfortable then,' said Stanford, who eagled the par-5 hole on Friday. 'The first six holes I was a little uncomfortable.'
Stanford, currently the 108th-ranked player in the world, followed up her first birdie with 20-foot birdie putts at the eighth and ninth holes to make the turn at 15 under.
After birdies at 10 and 11 moved her further into red numbers, Stanford dropped her only shot of the round at the par-4 13th, where she missed the green on her approach and then pushed a short par putt wide.
'I was never comfortable,' Stanford said of the hole.
She rebounded two holes later with a birdie at the par-4 15th, where she landed a pitching wedge within 8 feet. Stanford's four-shot lead was wrapped up at the 18th with a 7-foot birdie.
'Making a birdie on 18 was very important...because I think the more shots you can get on these ladies, the better off you are,' said Stanford, whose only LPGA win came at the 2003 ShopRite LPGA Classic -- one week before she lost to Hilary Lunke in a playoff at the U.S. Open.
Brittany Lincicome and Lindsey Wright share seventh place at 12-under-par after rounds of 66 and 68, respectively.
Kraft Nabisco champion Karrie Webb (70) and her playoff foe at the year's first major, Lorena Ochoa (67), are tied again, sharing ninth place at minus-11.
Christina Kim fired the low round of the day with an 8-under 64 and leads a group of three players tied for 13th place at 9 under.