Rob Johnson finished one shot back after a round of 70. Doug McGuigan, Brian Unk, Chris Wall, Steve Schneiter and Ben Ferguson followed at 1-under-par 71.
Compton started on the 10th under windy conditions at Brookside Country Club and collected a pair of birdies over his first nine holes.
The 24-year-old, who won the Michelin Guadalajara Classic in 2003, added two birdies on the front side before a bogey at the ninth dropped him back into a share of first.
'On a day like today, with that wind, par is your friend,' said Compton. 'The thing is, when you see how everyone else is struggling in those conditions, you can tend to play that way as well. I play an aggressive game anyway, but I still felt there were a few holes out there you could birdie. But there are also some holes you have to play smart to make par.'
Oppenheim also played the back nine first and tallied three birdies en route to a bogey-free round of 69.
Ben Gallie, Wes Martin and Stephen Woodard shared ninth place at even-par 72.
Local favorite Ricky Barnes, the 2002 U.S. Amateur champion, was one shot further back in a group at 1-over-par 73.