Moore teamed with Spencer Levin and Lee Williams to shoot an 8-under 136 on the Ocean Course at Rio Mar Country Club, giving them a two-day total of 20-under-par 268. Spain stands alone in second place at 12-under-par 276 followed by Sweden, Wales and Switzerland at 9-under-par 279.
Moore jumped out of the gate with a birdie at the par-4 first, but gave a shot back with a bogey at the very next hole. The 21-year-old, who won this year's U.S. Amateur and U.S. Public Links Championship, recovered with a birdie at the par-5 fifth and kept plugging along with back-to-back birdies starting at the par-4 10th.
He picked up another birdie at the 15th and Moore capped off his round with a birdie at the par-4 18th.
'Everybody's score has counted,' said Moore. 'There are not A, B or C players in this group. Anybody can shoot 63, 64 or 65.'
Levin torched the front side of the Ocean Course with four birdies. He stumbled to back-to-back bogeys from the 11th, but countered with a birdie at the 15th for a round of 69. Williams, who carded a 67 in the opening round, managed only a 73 in round two.
Rafael Cabrera-Bello paced the Spaniards on Friday with a round of 68. Alfredo Garcia added a 71 and Alvaro Quiros' round of 75 was dropped from the team total.
The Italian team stumbled with a 2-over 146 to finish 14 shots back at 6-under-par 282.
Australia, Germany and England share seventh place at 5-under-par 283.