This is the first time in his career that Villegas has been ranked among the top 20 players in the world.
The top eight remained the same with Tiger Woods, Phil Mickelson, Vijay Singh, Padraig Harrington, Sergio Garcia, Henrik Stenson, Ernie Els and Steve Stricker.
Jim Furyk tied for third behind Villegas which gave him a four-spot bump to No. 9. Stewart Cink slipped a spot to 10th, while Anthony Kim, who shared third with Furyk at the BMW Championship, climbed four to No. 11.
Lee Westwood held steady at 12. Geoff Ogilvy slid three places to 13th and Justin Rose held on the 14th position. Adam Scott tumbled four slots to 15th and was followed by K.J. Choi and Kenny Perry, who both remained in the same spots as last week.
Villegas soared to 18th and was followed by Miguel Angel Jimenez and Trevor Immelman, who dipped one spot apiece.