Webb, who started the day with a five-shot lead, was never challenged over the final 18 at the Royal Pines Resort. The world's top-ranked player carded three birdies against no birdies for a 72-hole total of 17-under-par 271.
The 26-year-old Webb joined England's Laura Davies as the only women golfers to win the same event four years in a row. Davies reeled off four straight victories at the Standard Register PING from 1994-97.
'I only had two bogeys all tournament and I can't complain with 17-under, although I probably hit the ball better than I putted this week,' Webb said. 'But it's a good kick-start to the year -- hopefully it's an omen and a sign of things to come.'
Webb, whose victory here a year ago was her third in three starts to begin the 2000 season, has yet to win in five LPGA Tour starts this year. Although this event was considered an LPGA event last year, it is not part of the official schedule in 2001.
Teske turned in a 69 for second place at 9-under 279, one stroke better than Scotland's Catriona Matthew, who closed with a 4-under 68. Matthew captured her first LPGA Tour title two weeks ago at the Hawaiian Ladies Open.
American Kelly Robbins finished alone in fourth at 7-under, while Aussie Corinne Dibnah and Kathryn Marshall of Scotland tied for fifth place at minus-five.
New Zealand's Lynnette Brooky, the leader by four strokes after Friday's second round, posted rounds of 76-78 over the weekend to finish 14 shots off the pace at minus-three. First-round leader Diane Barnard of England ended the event at minus two.