'I am still in shock. I just couldn't get any of my shots to go,' Wie said after a round of 8-over 79. 'I don't know why it was. I don't even know what sport I was playing today.'
Having now missed the cut in nine of the 10 men's events she has played worldwide, Wie will give it another shot next week at the 84 Lumber Classic on the PGA TOUR.
'I feel like I know what I have to work on and I know what I have to do next week,' said Wie, who made her only cut against the men in May at the SK Telecom Open on the Asian Tour.
'I have got to get my shots back into the fairway. I'm going to work hard for next week.'
Laura Davies, the only other woman to play in an event sanctioned by the European Tour, missed the cut and finished second-to-last at the ANZ Championship in 2004.
Friday, Wie was dead last out of 152 players.
'Days like this don't scare me away,' she defended, 'they just make me more motivated.'