Much like the first day at Formby Golf Club, Great Britain & Ireland took the morning foursomes to square the matches at 6 - 6. The Americans proved to be too much in the afternoon singles, however, winning four of the six matches to improve their all-time Curtis Cup record to 24-6-3.
'We clearly didn't master the foursomes formula on this golf course,' said U.S. captain Martha Kirouac. 'We did the best we could. I pretty much just wanted to get to the singles matches this afternoon and then I knew we'd be all right.'
Wie won the first hole in her afternoon match and took control later on the front nine. She won three straight holes starting at the fifth and held on for a 4-up advantage around the turn.
The 14-year-old converted a short birdie putt at the par-4 11th to go 5-up and won the following hole with a par. The match was then decided on the 13th.
Paula Creamer led off the afternoon singles against Emma Duggleby and won the ninth to take a 2-up lead on the front side. Creamer then birdied the par-4 15th to go 3-up and parred the 16th to secure another point for the Americans.
Anne Laing got one back for Great Britain & Ireland with a 3-and-1 win over Jane Park, but Elizabeth Janangelo knocked off Shelley McKevitt, 1-up, to give the Americans another win.
'It meant a lot to me for Martha to have the confidence to put me in the lineup,' said Janangelo. 'I hadn't been playing all that well, but I felt I could come through.'
Brittany Lang held a 2-up lead through 12 holes, but the American let Claire Coughlan back into the match. Coughlan won the 14th with a birdie and squared the match with a par at the very next hole.
Coughlan then took a 1-up lead at the 17th and birdied the last to give Great Britain & Ireland a point after a 2-up win.
In the last match of the afternoon, Annie Thurman trailed Great Britain & Ireland's Danielle Masters on the inward half but battled back to win her match, 1-up.
'I'm disappointed we lost but it was a close match,' said Great Britain & Ireland captain Ada O'Sullivan. 'I kept living in hope that something might happen but in the end it was too late.'
The Curtis Cup is a team match play competition for women amateurs contested biennially between the United States and Great Britain & Ireland that began in 1932. The 2006 Curtis Cup will be held at Chicago Golf Club in Illinois.