'I am still in shock. I just couldn't get any of my shots to go,' Wie said after a round of 8-over 79. 'I don't know why it was. I don't even know what sport I was playing today.'
Having now missed the cut in nine of the 10 men's events she has played worldwide, Wie will give it another shot next week at the 84 Lumber Classic on the PGA TOUR.
'I feel like I know what I have to work on and I know what I have to do next week,' said Wie, who made her only cut against the men in May at the SK Telecom Open on the Asian Tour.
'I have got to get my shots back into the fairway. I'm going to work hard for next week.'
Laura Davies, the only other woman to play in an event sanctioned by the European Tour, missed the cut and finished second-to-last at the ANZ Championship in 2004.
Friday, Wie was dead last out of 152 players.
'Days like this don't scare me away,' she defended, 'they just make me more motivated.'
At the top of the leaderboard, it was an international affair with the Welshman Dredge, the South African McLardy and the German Siem sharing the top spot at 7-under-par 135.
McLardy fired a 6-under 65 with eight birdies and two bogeys in his second round, moving up from a tie for 28th place overnight.
'This was huge. I knew if I could make one more cut I would basically have my card (for next year),' said McLardy, who currently ranks 118th on the Order of Merit.
'They say take one shot at a time and don't think about it, but of course you think about it. It is a great confidence boost...my lowest round of the year.'
Dredge and Siem had matching 4-under 67s to move from a tie for eighth place into a tie for the lead. Dredge had five birdies in the round, all on his final nine holes, while Siem mixed six birdies with two bogeys.
'Last week I decided to leave my swing alone and go back to what I was doing before,' said Dredge, who made his first cut in five starts last week. 'Straight away I have seen some results. It's tough -- you are trying to improve but it is not always in the swing, it is a culmination of everything.'
Siem credits an unlikely source for a recent positive turnaround in his play: a feature on himself in European Tour Weekly.
'ETW is good fun,' he admitted. 'You don't feel like a nobody...if people want to talk to you, you must be a good player and maybe that helps give you confidence.'
Francesco Molinari, a stunning winner at the Italian Open in May and the younger brother of 2005 U.S. Amateur winner Edoardo, is alone in fourth place at 6-under 136 following his second consecutive 68.
One stroke further back, defending champion Sergio Garcia lead a group of three players who are tied for fifth place. Garcia, who owns a cottage just yards from the first tee, began his round with a 55-foot eagle putt on the first green.
'I have to go out and keep giving myself good chances, taking advantage of the par fives,' said Garcia, who shot a 69 Friday. 'Hopefully [I'll] have a lot of eagle putts.'
The cut line fell at plus-1 with 66 players moving on to the weekend. Among those missing the cut was Edoardo Molinari.