Woods battled food poisoning, which caused him to get physically ill several times on the course, and fought through heavy rains to claim his fourth consecutive Bay Hill title.
He became the first player to win the same tournament four years in a row since Gene Sarazen won four in a row at the Miami Open from 1926-30. The 1927 event was not held.
Woods has now been ranked No. 1 for 188 consecutive weeks and 258 weeks overall. He stretched his margin over World No. 2, Ernie Els, from 7.28 points to 8.40 points.
The remainder of the top five, Phil Mickelson, Vijay Singh and David Toms, remained the same. Retief Goosen and Davis Love III also stayed put at Nos. 6 and 7.
Mike Weir and Sergio Garcia flip-flopped the eighth and ninth positions, while Padraig Harrington and Jim Furyk remained in the 10th and 11th slots.
Chris DiMarco jumped one space to 12th and Justin Leonard moved up two spaces to 13th. Nick Price held steady in the 14th slot, while Scott Hoch fell three spots to 15th.
Colin Montgomerie climbed two notches to No. 16 and Charles Howell III remained in the 17th space from a week ago. Rocco Mediate slipped two spots to 18th, while Jerry Kelly remained No. 19.
Kenny Perry, who tied for second behind Woods at Bay Hill, climbed 10 spaces to No. 20.
Bradley Dredge, who won the Madeira Island Open on the European Tour, improved 17 slots to No. 55. Kirk Triplett, who shared second with Perry, Brad Faxon and Stewart Cink, was the big mover in the top-100 as he leapt 26 spots to No. 59 in the world.