Brooks Koepka announced Saturday via Facebook that he has withdrawn from next week's Open at Royal Troon because of a torn ligament in his right ankle.
It's the same tear that caused to Koepka withdraw from last week's WGC-Bridgestone after 13 holes.
"I have been consulting with my doctor, trainer, and my entire team over the past week. We all feel this is the best decision at this time," Koepka posted.
He will be replaced in the field by Colt Knost, who will make only his second major start and his first at The Open.
Koepka, separately, wrote that he will undergo rehab for his injury and hopes to be back by the PGA Championship from July 28-31.
The 16th-ranked player in the world was coming off a stretch of hot play following back-to-back runner-up finishes at the AT&T Byron Nelson and FedEx St. Jude and a tie for 13th at the U.S. Open. He currently occupies the eighth and final automatic qualifying spot on the U.S. Ryder Cup points list.
"I wish everyone the best of luck next week at Royal Troon and I look forward to seeing everyone at Baltusrol," he wrote.