The two most recent winners on the PGA Tour, Aaron Wise and Webb Simpson, missed the cut at the Fort Worth Invitational on Friday.
Wise and Simpson both came up short of the 2-over total by a shot following rounds of 70-73.
Wise was safely inside the number before playing his last four holes in 4 over par with two bogeys and a closing double following a trip into the water at the par-4 ninth.
Simpson, making his first start following his Players triumph, similarly struggled coming home, bogeying three of his final six holes.
Other notables who won't be around for the weekend at Colonial include Xander Schauffele (+4), Jason Dufner (+5), Patrick Cantlay (+6), Smylie Kaufman (+13), and Sam Burns (+13).
This is Kaufman's 11th consecutive MC and his 15th in his last 16 starts.