Kevin Stadler, who won last week's Xerox Classic, is one stroke back after an opening round 65. Brad Adamonis, Richard Johnson, John Mallinger, David Mathis and Brian McCann share fourth place at five-under-par 66.
Wagner, who has won the Louisiana Open and the Cox Classic this year, opened with a birdie on the par-five first. After a pair of pars, he ran off three straight birdies from the fourth at Glenmaura National Golf Club.
The 26-year-old climbed to minus-five with a birdie on the par-three 11th. Wagner made it two straight with a birdie on 12. He claimed his share of the lead with a birdie at 16.
'I played great today, made a lot of 20-footers for birdie and when they didn't go in they looked like they had a chance,' Wagner stated. 'Today was a dream putting round. Other than Sunday in Omaha (Cox Classic), that's probably the best putting round I've ever had in a tournament.'
One more win this year for Wagner and he'll be off to the PGA Tour thanks to the Battlefield promotion. Jason Gore earned that promotion with three wins in 2005.
'It's been on my mind since a couple weeks ago, but I try to put it out of my mind these next three days and just play my game,' admitted Wagner.
Daley, who ended second at the Charity Pro-Am at The Cliffs for his best finish this year, got on the board with a birdie on the fourth. He birdied three in a row from the sixth to make the turn at minus-four.
The 28-year-old, who is still searching for his first tour win, birdied the 11th and 13th to move within one of the lead. Daley joined Wagner at seven- under with a birdie at the par-three 15th.
However, he gave that stroke right back with a bogey on 16. Daley regained a share of the lead as he birdied the last to finish at minus-seven.
'It was nice to finish off that way,' said Daley of his closing birdie. 'The tee shot (on 16) could have killed my momentum, making worse than bogey. So that got me going again.
'Hit another good shot on 17 to about 12 feet, but that putt didn't go in. But 18 was nice. It was nice to close it out that way.'
Bradley Hughes opened with a four-under-par 67. He was joined in a tie for ninth place by P.H. Horgan III, Craig Kanada, Brad Lamb, Jeremy Pope, Todd Rossetti, Steve Wheatcroft and Brett Bingham.