Dickerson completed 36 holes at 14-under-par 130, two strokes of the 36-hole record.
Henrik Bjornstad also shot 68 to move into second place at minus-10. Bret Guetz (66) and Roger Tambellini (70) share third at 9-under-par 135. Ten more players are one shot back at minus 8.
After opening with a 62, Dickerson picked up where he left off in round one. He birdied the par-4 10th from four feet out to move to 11-under. However, he tripped to a bogey at the next.
Dickerson birdied 15 and 17 at The Dominion Club to make the turn at 12-under. Around the turn, he pulled away from the field with three birdies in a four- hole span from the first.
After that run got him to 15-under, Dickerson faltered to a bogey on the fifth, his 14th. He parred the final four holes to post 14-under and become the first player in event history to hold the 18- and 36-hole leads.
'I probably hit the ball as well as I did yesterday,' said Dickerson. 'I seemed to be in between clubs a lot today.
'Obviously, 14-under on this golf course is pretty good golfing. There's a lot of rough out there and I've been lucky enough to keep it out. I've hit a lot of good shots and I'm making some putts.'
Bjornstad also played the back nine first. Birdies on the 11th and 18th helped him make the turn at 8 under.
He birdied the first, but gave that shot back as he bogeyed No. 3. Bjornstad erased that mistake thanks to a birdie on the fourth. A birdie at the sixth got him to 10-under and he parred out from there.
'I've been hitting the ball a lot better than I did last year,' Bjornstad admitted. 'My putting is also getting to where I want it.'
Scott Gutschewski fired a 6-under 66 to jump from a share of 40th into a tie for fifth at 8-under-par 136. He stands alongside Greg Chalmers, Chris Riley, Kris Blanks, Gary Christian, Matt Hansen, Wade Ormsby, Brad Fritsch, Keoke Cotner and Bryan DeCorso.
The cut fell at 2-under-par 142 with 72 players moving on to the final two rounds.