Rosie Jones, whose quest for a major title remains unfulfilled, managed a 1- under 71 to finish alone in second place at 7-under-par 281. Laura Diaz and Cristie Kerr shared third place at 5-under-par 283.
Sorenstam has dominated women's golf throughout her career and has set several records along the way. Sunday's win was the fifth in her last five starts, dating back to the ADT Championship last November, putting her in an elite group with Nancy Lopez as the only players to win five consecutive starts.
'I'm very excited, I'm very happy. I had a lot of things go right this week,' said Sorenstam, who won for the 59th time on the LPGA Tour. 'I've been driving down the street, it's been green lights, everything is perfect. Good music on the radio, you name it.'
Sorenstam took control of the event with a 66 on Saturday on the Dinah Shore Course at Mission Hills Country Club. She carried a five-shot lead over Jones into the final round and continued to pull away with a birdie at the par-5 second after her third shot stopped within 5 feet of the hole.
The Swede knocked her second shot inside 7 feet for a birdie at the par-4 fourth and converted an 8-foot putt for a birdie at the par-3 fifth to extend her advantage to eight strokes.
'It was a very good week when it comes to the rhythm of my swing, the distance control was good,' said Sorenstam.
Sorenstam buckled down from that point on and added a birdie at the par-5 11th to reach 15 under. She caught an unlucky bounce at the par-4 13th but drained a par-saving putt from the fringe. Sorenstam continued to string along pars until the closing hole.
Sorenstam had a birdie chance at the last but she two-putted for par before the celebratory jump into the lake alongside the green.
'I want to enjoy this,' said Sorenstam, who captured her eighth career major title. 'Who knows what will happen the rest of the year.'
Jones could only hope for a meltdown from Sorenstam on Sunday to have any chance at a comeback. She hurt herself early with a bogey at the fourth, however, but came back with a birdie at the very next hole.
'I had to get off to a really good start,' said Jones, a 13-time winner on the LPGA Tour. 'I wanted to come out and play aggressive.'
The 45-year-old ran off back-to-back birdies starting at the par-five ninth to move to 8 under. She then gave a shot back with a bogey at the par-4 15th and parred her way in to take second place alone.
'She didn't show any nerves at all,' Rose said of Sorenstam. 'It would have been nice to come within three or four shots of her and put a little more pressure on her, but that didn't happen.'
Defending champion Grace Park completed a valiant effort on Sunday with a 4-under 68. Park, who was forced to pull out of last week's Safeway International because of a bad back, joined Mi Hyun Kim in a tie for fifth at 4-under-par 284.
Juli Inkster was one more shot behind at 3-under-par 285 followed by Lorie Kane at 2-under-par 286.
Beth Daniel, Reilly Rankin, Dorothy Delasin, Candie Kung and Wendy Doolan tied for ninth at 1-under-par 287.
Michelle Wie had a streak of top-10 finishes at this event snapped but the 15- year-old was still able to finish as the low amateur. Wie carded a 1-under 71 in the final round to share 14th place with Kim Saiki and Brandie Burton at even-par 288.