Derek Gillespie (66), Cory Jones (69), Alex Quiroz (67) and Conrad Ray (63) shared fourth place at 9-under-par 275.
Compton, who trailed overnight leader Jorge Corral by four strokes, went 3-under on his first nine to overtake Corral, who struggled to a 78 on Sunday. While playing the back nine, Compton pulled clear of the field and then it was a matter of keeping his emotions together.
'This whole week, I played like I did today except I couldn't get the putts to fall,' said Compton, who earned his Canadian Tour card with a third-place finish at the Winter Qualifying School. 'Once I got off to the quick start, I think it pressed the guys behind me a bit. I've never been in this position before as a pro, so I had to keep my emotions in check.'
Compton has had a difficult path to this win. He underwent a heart transplant at the age of 12 and his brother broke his neck skiing two days before the Winter Q-School.
'I think I will give my brother, dad and mom a call, this is a pretty nice Mother's Day present,' said Compton. 'My family and my girlfriend are back home ready to pop a bottle of champagne, regardless of what happened here today. I felt really good coming into this week, and those good vibes paid off for me.'
Josh Habig (66), Alex Rocha (69) and Roger Tambellini (71) tied for eighth place at 8-under-par 276.
Corral shot a 7-over-par 78 and fell into a tie for 20th place at 3-under-par 281.