He stands at 10-under-par 130 and is three ahead of Scott Parel, who fired a 65 in round two. Justin Bolli, who won last week's event in Pennsylvania, carded a 64 on Friday and is alone in third at minus-5.
There was another weather delay on Friday. Thursday's stoppage was nearly 90 minutes long and Friday's was 10 minutes longer. The players once again barely finished, but the whole field completed the second round.
Driscoll, who shared the overnight lead with Hunter Haas, broke into red figures for the first time in the round at the par-5 third. His 6-iron second missed the green, but he chipped to 5 feet and holed the birdie putt.
His next birdie came at the par-4 fifth when he sank a 12-footer. Driscoll parred his nine in a row around the turn, then the horn sounded when Driscoll had four holes to play.
And it was an adventurous four holes.
He hit a 4-iron over the green at the par-3 15th and could only chip to 12 feet. Driscoll made that par save, then holed another par putt from half that distance at 16 to keep his lead at minus-8.
At the par-4 17th, Driscoll hit a 9-iron to 11 feet to set up birdie. He closed his round with two in a row thanks to a 14-footer at the 478-yard closing hole.
'I made two birdies and two pars after the break,' said Driscoll, whose only win on the Nationwide Tour came at the 2004 Virginia Beach Open. 'I got a lot of out of those four holes...a productive delay.'
Jason Day (66), David Hearn (69), Mark Wiebe (69), Keoke Cotner (64), Fran Quinn (67) and David Mathis (69) share fourth place at 4-under-par 136.
Haas struggled to a 4-over 74 on Friday and fell into a tie for 14th place at minus-2.
The 36-hole cut fell at 2-over-par 142 with 66 players making it to the weekend.