The tournament has been plagued by delays and suspensions since Thursday, when first-round action was suspended and officials have been trying to make up the time. Friday's action was suspended for darkness and most players had to complete their second rounds on Saturday.
Players will return to position 7:30 AM (ET) Sunday to finish the third round. The final round is scheduled to tee off at 11:00 AM with the final group set to go off almost an hour later.
David Morland IV is alone in second place at 11-under through nine holes. Former PGA Tour veteran Dennis Paulson is 10-under through 15 holes, Brett Wetterich is 10-under through 10 and Joe Ogilvie is at that score midway through his round.
Dufner carded a second-round 66 on Saturday and held a two-shot lead at the start of the third round. He collected eight straight pars to open his third round at the TPC at Wakefield Plantation before he knocked a wedge to six feet at the ninth to take sole possession of the lead.
'I hit a lot of greens this morning but didn't drive it quite like I like to,' said Dufner. 'I made some nice putts, some long ones today. I really wanted to finish out there at nine.'
Dufner is one of the hottest players on the Nationwide Tour with three top-5 finishes in his last three starts. He tied for fifth at the Rheem Classic and tied for fourth at both the Charity Pro-Am at The Cliffs and the Virginia Beach Open.
'Everything's been coming along for me,' said Dufner. 'I had a good chance to win in Fort Smith (Rheem Classic) but didn't get it done on Sunday. The last two weeks I've just been hanging around.'
Vaughn Taylor, Paul Claxton, Mark Wurtz, Kevin Johnson and D.J. Brigman are tied for sixth place at 9-under par and all five still need to complete their third rounds.