Paul Claxton, Zach Johnson, David McKenzie and Wes Short tied for second place at 7-under-par 277.
Ogilvie, the Nationwide Tour's leading money winner, opened the round with a two-stroke advantage. That lead doubled when he eagled the par-5 first on the East Course at the Country Club of Hershey.
After four straight pars, Ogilvie rolled in a birdie at the par-5 sixth to get to 12-under. He maintained a four-stroke lead through to the back nine as he ran off nine consecutive pars around the turn.
'After the birdie at six, I figured nobody's going to get to 12-under,' said Ogilvie, who has nine top-25 finishes in 11 starts this season. 'This golf course is too tough and the greens were getting very fast. My mental state changed from attack to defend. I didn't think anyone was going to shoot 66 so I figured I'd just par them to death.'
Ogilvie, who played on the PGA Tour the last four seasons, stumbled to the clubhouse with bogeys at 16 and 18 but it did not matter.
Ogilvie, who won the season-opening Jacob's Creek Open Championship, is one win from gaining the Battlefield Promotion to the PGA Tour. Last season, Patrick Moore became the fifth player in Nationwide Tour history to earn that promotion.
'I won twice out here in 1998 but those were my only two good tournaments all year,' said Ogilvie, who earned $81,000 with the win. 'This is by far the best golf I've played.'
Short, who survived on the cut line of plus-1, made a huge move on the weekend. He fired a 6-under 65 in the third round to move from a tie for 57th into a tie for sixth. On Sunday, he birdied the fifth and sixth to move to 7-under.
It looked as though he would be able to make another strong run, but he parred the next six holes. Short then dropped a shot at the par-3 13th but rebounded from that error to birdie the 17th to share second place after a final-round 69.
Claxton, who was two groups ahead of Short, birdied the first to get to minus-6. However he bogeyed the third and seventh to drop off the pace. He came back to birdie Nos. 9 and 11.
He then posted back-to-back birdies from the 14th to get to eight-under. Claxton's momentum ended quickly though as he bogeyed the 16th before parring the final two holes for a 69.
Johnson and McKenzie played together in the penultimate pairing. Johnson played a steady round. He posted birdies on the fifth and 12th, but dropped a shot at the 15th. Johnson finished with a 70.
McKenzie struggled on the front nine. He bogeyed the fourth and seventh to fall down the leaderboard. He began his climb back to a share of second with three straight birdies from the par-4 ninth. McKenzie birdied the 13th to get to 8-under, but fell back with a bogey at the 16th. He also posted a 70 in Sunday's final round.
Michael Christie and Anthony Rodriguez tied for sixth at 6-under-par 278. Scott Gump and Charles Warren shared eighth place one stroke further back at minus-5.