'I am very happy, it has been a very good week,' said Sorenstam, who becomes the first LPGA player to win two different events three straight times. 'I played well the first day to the last day. I came here to set many more records. The Mizuno Classic has been a good tournament to me.'
Grace Park, who was the runner-up to Sorenstam at this event last year, posted a 4-under 68 to join Sophie Gustafson and Se Ri Pak nine shots back in a tie for second at 15-under-par 201.
Sorenstam put the tournament out of reach after opening with back-to-back rounds of 63 at Seta Golf Course to carry a six-shot lead into the final round.
She parred her first five holes before picking up her first birdie of the day at the par-5 sixth. Sorenstam then birdied the par-3 ninth to make the turn at 20 under.
The Swede kept on cruising on the back side with a birdie at the 13th and another birdie at the 15th.
Sorenstam then closed the round in the same way she did on both Friday and Saturday. She birdied each of the last two holes to cap the commanding victory and finish the tournament without a bogey.
'This was the first time I had no bogeys for 54 holes and the first time I had no three putts for 54 holes, so I was very consistent and solid,' said Sorenstam, who ties Nancy Lopez for sixth place on the LPGA all-time wins list.
'My goal every year is to win the money list, the Vare and the Player of the Year,' said Sorenstam, who earned $169,500 for her sixth win of the season. 'Se Ri is going to play a couple more than me, so for me to win here was very important. I am wrapped up for Player of the Year and I've played the best I can all year. I am disappointed that I cannot win the Vare Trophy because I won't get the required number of rounds.'
Yuri Fudoh carded a final-round 69 to finish alone in fifth place at 14-under-par 202. Rachel Teske was one shot further back at 13-under-par 203.
Gloria Park and Jung Yeon Lee shared seventh place at 12-under-par 204. Soo- Yun Kang followed at 11-under-par 205.
Lorena Ochoa, Dorothy Delasin and Christina Kim tied for 10th place at 10-under-par 206.