Joe Durant fired a 7-under 65 to jump into a tie for second place at 9-under-par 135. He was joined there by Brad Faxon, who shot 67 in round two.
Trahan, who led after round one for the second time in his PGA TOUR career, is on top after two rounds for the first time in his career.
He got going on the back nine Friday at Annandale Golf Club. Trahan collected his lone birdie of his opening nine at the par-5 11th.
Trahan parred the next 11 holes from there. He was 8 under and one stroke behind Durant and Faxon, an eight-time winner on the PGA TOUR. Trahan joined that pair in the lead with a birdie on the par-5 ninth.
The 25-year-old, who finished 12th here last year, move one ahead with a birdie on the par-5 seventh. After converting a stellar par-saving putt on the eighth, Trahan drained a 20-footer for birdie on nine to close a bogey-free round and take a two-stroke lead after two rounds.
'I hit the ball very well and I gave myself plenty of opportunities,' Trahan stated. 'I just couldn't get the putts to fall. I misread a couple of them and hit a couple good ones that didn't go in. I stayed patient and didn't get frustrated at all.'
Durant, a three-time winner on TOUR, also played the back nine first Friday. He opened with birdies on 10 and 12, before faltering to a bogey on the 13th.
The 42-year-old birdied No. 14, then collected birdies on 17 and 18 to make the turn at 6 under. Durant traded a birdie for a bogey from the third.
Durant rolled in a birdie putt on the sixth, then eagled the seventh to end at minus-9.
Faxon birdied the first, then picked up another one on the third.
The 45-year-old drained back-to-back birdies from fifth to move to 8 under. Faxon birdied the par-5 11th and notched the final birdie of his round at the 13th.
Faxon stumbled to a bogey on the 14th, his second in two days on that hole. He closed with four straight pars to share second place.
'It was a great start. It was cold this morning and I actually thought it was going to be our disadvantaged,' admitted Faxon. 'Not only was it cold, I thought the wind was going to kick up a little bit. But it just kept getting nicer and nicer. I got off to great start. When you can birdie right out of the box it's nice.'
Troy Matteson used a 6-under 66 Friday to jump into a tie for sixth at 6-under-par 138. He was joined there by Ted Purdy (70), Nick Watney (71) and Robert Damron (69).
Former world No. 1 David Duval posted a 3-under 69. He is tied for 10th at minus-5 with 12 other players including Fred Funk, Jason Gore, Chris Riley and Lee Janzen.
The cut line fell at 1-over-par 145 with 81 players moving on to the weekend. Among those missing the cut were Bob Tway (146), John Cook (147) and 2005 champion Heath Slocum (148).