Staton is tied with Doug Barron (68), Charles Warren (65), Bill Lunde (68) and David McKenzie (66) at 8-under-par 136 at Whistle Bear Golf Club.
The five-player tie matched the Nationwide Tour record for most players sharing the lead after 36 holes. It happened three previous times, most recently at the 2002 LaSalle Bank Open.
Johnson Wagner fired a 6-under 66 on Friday to join Dave Cunningham, who shot a 67 in the second round, in sixth place. The duo is knotted at minus-7.
Staton was the final member of the leaders to get into the top spot. He collected four birdies against no bogeys to extend his fantastic fortune in Canada.
He won six times on the Canadian Tour and next May will marry his fiance, whom he met at the Canadian Open on the PGA Tour.
'Tee to green I played fantastic,' said Staton, who tied for fifth in The Reese's Cup Classic earlier in the month. 'I didn't make the putts I wanted to, but I had a lot of birdie putts.'
Barron made only one mistake on Friday. At the 10th, he hit an awful approach that cost him a bogey. Other than the hiccup at 10, Barron record five birdies.
'I won't say what I did on my second shot,' said Barron, refusing to call his approach to the 10th a 'shank.' That was my only mistake of the day. Other than that, I was happy with the way I played.'
Warren was flawless on Friday with seven birdies and no bogeys, while Lunde mixed six birdies and two bogeys in his round, all on his second nine.
McKenzie tallied seven birdies and one bogey in the second nine.
Ben Bates (67) and John Morse (67) are tied for eighth at minus-6, while Dave Christensen and Rob Bradley are knotted in 10th after matching rounds of two-under 70. That duo stands at 5-under-par 139.
Sixty-three players made the 36-hole cut, but three of the seven first-round co-leaders did not. Eduardo Herrera (76), Ryan Gioffre (76) and Kevin Durkin (78) missed the halfway cut, which fell at 1-under-par 143.