Rose finished T-19 last week at The Players Championship, highlighted by a closing 66. After that round, the Englishman spoke of his desire to someday win the European Tour's flagship event, which he described as his "home tournament."
But days later, he tweeted an explanation that an injury which had limited his third-round practice session at TPC Sawgrass to only 20 minutes had worsened.
"It is with deep disappointment that I must announce that I will not be able to play the BMW PGA Championship at Wentworth," Rose wrote. "I battled the onset of back pain all week at The Players Championship, and symptoms worsened during my week after at home. I have a great team of people around me who are working diligently to help me get as fit as possible as soon as possible, and I must fully focus on rehab at this time."
Speaking Sunday at TPC Sawgrass, Rose explained that the back injury is an old ailment that has impacted the 35-year-old with increasing frequency in recent months.
"This year it's flared up a couple of times," Rose said. "I think just because I seem to have a lot more speed this year, and I'm hitting the ball a lot further, a lot harder, that I just need to take care of it a little bit more, be very diligent with my gym stuff and training, just to stay on top of it."
Rose, like many players, is approaching a busy stretch of summer golf. While his statement did not include a target return to competition, his typical schedule would include a start at the Memorial Tournament in two weeks, where he lost last year in a playoff.
"Pending how I feel over the next several days, I am hopeful to make it out to Wentworth one day over the weekend to pay tribute to the tournament, volunteers and spectators," he wrote. "I wish BMW, the European Tour and all the players a successful event, and I thank them and my fans for the continued support."
Rose becomes the latest high-profile European to withdraw from next week's event at Wentworth. Rory McIlroy indicated last month that he would skip the tournament, while Ian Poulter has opted instead to tee it up at the Dean & DeLuca Invitational in Texas.