The event in Singapore will be held Jan. 28-31, the same week as the PGA Tour's annual stop at Torrey Pines. Spieth has played in San Diego each of the last three years, including in 2013 when he made his professional debut on a sponsor invite at age 19 after leaving the University of Texas.
He held the 36-hole lead in 2014 but missed the cut in his other two appearances, including this year during his five-win season, and will instead head to Sentosa Golf Club in January.
"Playing in the SMBC Singapore Open is something I'm really looking forward to," Spieth said in a statement. "I'm very fortunate to play golf around the world and can't wait to visit Singapore for the first time."
The tournament is sanctioned by the Asian Tour and was last held in 2012, when Matteo Manassero beat Louis Oosthuizen in a playoff. Other past champions include Adam Scott (2010), Ian Poulter (2009) and Angel Cabrera (2007).